Youngster: Welcome to my Mommy’s podcast.
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Katie: Good day and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the tip. And I’m right here right now with my buddy, Naveen, who’s an intensely curious entrepreneur who has been taking up some large, audacious concepts to push humanity ahead. He’s the writer of the award-winning guide “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Specific, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Clever, amongst others.
And his present work is in Viome Life Sciences, which was based in 2016 with a mission of creating sickness elective by predicting and stopping power illness by a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to stop and reverse power illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the 12 months, Most Inventive Individual by Quick Firm, Prime 20 Entrepreneurs, and lots of extra.
On this episode, we discuss in regards to the human ecosystem and customized optimization of your intestine well being and your total well being. We discuss in regards to the motive the intestine impacts your complete physique. Why it’s not simply genetics from our mother and father however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome steadiness begins at start and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.
The distinction between DNA and gene expression. How some meals might be good for some individuals and never others, and how you can know which is greatest for you, but in addition, the universally dangerous meals. Why there are some universality unhealthy ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The actual motive it’s necessary to chew your meals very well earlier than swallowing, and a lot extra. Lot’s of sensible information on this episode. Additionally, a number of hyperlinks to study extra within the present notes at wellnessmama.fm, so test these out. However with out additional ado, let’s be part of Naveen Jain. Naveen, welcome again.
Naveen: Nicely, Katie, so good to see you lastly after a protracted, very long time.
Katie: I’m so excited we get to have a dialog and get to report it and share it right now, and we’re gonna discuss lots about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one particular person I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply speak about this as a result of I believe you’re my solely hobbyist Moon rock collector.
Naveen: Nicely, I believe, Katie, , to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a approach of expressing that there’s nothing that’s inconceivable for us to do. Regardless that it’s known as “Moonshots” that individuals thought was troublesome, if not inconceivable to do and having, , now to have the ability to go to the Moon and to me, the gathering of area rocks really was simply merely a interest of in a position to maintain one thing in your hand. That could be even earlier than the start of our planet. And it provides you some concept of how fragile we’re that if we don’t handle ourselves, our planet, we as humanity could not survive. As a species, we could not survive.
So, , concept of when somebody says, “I’m actually frightened about our planet,” ask the planet and planet will let you know, “Don’t you are worried about me as a result of we…” Planet will just do high-quality however human species could not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are related collectively. When one thing exterior us goes incorrect, we as inner ecosystem can even be impacted, proper. And that’s coming right down to, , should you take a look at what’s above, so beneath is basically what’s exterior the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.
Katie: I like that you simply mentioned it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and him as properly. And I requested him that query. You already know, your era’s gonna face lots within the environmental and local weather stuff. And, I raised this query and he goes, “Nicely, mother, you’re really asking the incorrect query as a result of the…”
Naveen: Oh, I like it, I like it.
Katie: He mentioned, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we have to be asking how we might be extra synergistic inside an setting that’s greater than us.”
Naveen: That’s the excellent reply. That’s precisely how I might see it that…, when individuals say, “Aren’t you frightened in regards to the planet?” I say, “That’s not the query you ought to be asking.” It’s, “Are we frightened in regards to the human species?” That’s what we needs to be asking.
Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not frightened about however working to resolve. My listeners are fairly well being savvy and perceive or at the very least have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…properly, we’ve identified elements of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…due to corporations like Viome, we’ve many extra tangible instruments to truly perceive and begin to do one thing about that. However to begin broad, type of give us an summary of what we imply by the well being of the intestine impacts the well being of the entire physique.
Naveen: So, properly, initially, , let’s simply begin from the start. We as human beings are usually not merely a product of the DNA from our mother and pa. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which might be really expressed in our human physique are usually not our personal. They arrive from these microbes which might be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such by way of all of the genes which might be expressed that makes us who we’re, they aren’t people. They’re largely microbial. We’re residing of their world. They don’t dwell in our world, proper.
So, once we perceive that, , though you might argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you might argue sometime that possibly they really created us to unfold them round, possibly they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and cozy place to remain. In flip, they feed us the vitamins that our physique wants to truly be wholesome, proper. So, think about from the time a child is born, and I believe that is one thing that most individuals don’t understand, that within the first couple of days of mom’s breast milk is filled with oligosaccharides. And that can not be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Meaning it’s to create the ecosystem inside us.
Now think about what nature is telling us, that we simply created a offspring and the easiest way to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by the start canal, that is the primary publicity the child will get to the entire world of microbiome. It will get…fully inhales the microbiome because the child’s going by start canal. And sadly, a few of the moms for apparent causes find yourself getting a C-section. They really…the infants are usually not going by the identical…they’re uncovered to pores and skin microbiome relatively by the start canal, the microbiome that they’d get by the start canal. And that may be a basically…the child, when it’s born, is definitely…the character has created in a approach that the microbes get launched into the child on the time of the start and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.
And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I believe that is the elemental half that individuals want to know. Seventy p.c of our immune system is alongside our intestine lining. In truth, all of the analysis reveals that how intestine microbiome is continually coaching our immune system what’s a buddy and what’s a foe, proper. So, in some sense, should you take a look at the human physique, there’s a tube that goes by us. There’s a high of the tube in your mouth after which there’s the underside of the tube, and then you definately begin to take a look at all alongside the strains there’s a large quantity of microbial existence there. They usually actually are continually interacting with our immune system and the immune system is now understanding when there’s really a pathogen that’s coming by the meals or the pathogen that’s coming by the surface world, how you can react to it. And these microbes are the primary sign that tells the immune techniques, “This isn’t good. Go do one thing about it, proper.”
And I believe to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I believe as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we minimize our pores and skin or whether or not there’s some sort of pathogen or we get some sort of a illness, it usually is designed to heal itself if our physique is in steadiness. So, when there are intestine microbial actions and the human host are continually in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique isn’t comfy, you get illness which we name illness.
Katie: Yeah, so many necessary factors you simply mentioned to unpack. And I believe the primary being that we actually are extra bacterial than human and also you…right here you mentioned you might be what you eat however it goes thus far past that. It’s not even you might be what you eat and even you might be what you eat-eat, however what your intestine micro organism eats and the way it grows. And I like that you simply introduced up the start canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the child, as a result of such as you mentioned, should you don’t…the child is of course meant to seed their intestine by the start canal. And if that doesn’t occur, such as you mentioned, they’re seeding to the hospital room, to pores and skin, to probably disinfectants which might be in that room, every kind of issues. And we all know that this intestine micro organism at start, increasingly more we study, units you up on your complete life. But in addition, the excellent news is…and I do know that Viome does a number of analysis on this. All isn’t misplaced should you don’t get an ideal begin. We now have the flexibility to type of get a snapshot and look within the intestine in a very distinctive approach after which optimize to enhance somebody’s well being going ahead.
And likewise, such as you mentioned, the physique’s pure state is well being. It’s not typically that we have to do something drastic. We have to get out of our personal approach and simply take away the issues which might be preserving the physique from being wholesome or possibly generally give it little further vitamins to assist get there. Discuss a bit of bit in regards to the science of Viome and what we’re testing as a result of this expertise didn’t even exist a pair a long time in the past, and now we’ve such wonderful knowledge from this.
Naveen: Nicely, it’s very attention-grabbing is this concept of, …should you return and take a look at couple of a long time in the past, it was really the micro organism and all these organisms had been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as rapidly as doable as a result of they’ll’t presumably be there for our good, proper. And as we began to study extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re purported to be there they usually actually…once we feed them issues like, …in olden days, once we had been residing within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the basis and eat it. That’s filled with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these had been all of the vitamins that our physique wanted.
In truth, should you begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, should you actually take into consideration all of the issues which might be being performed within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you simply identified. What occurs in our intestine impacts our temper. So, whether or not it’s a melancholy or nervousness or, , you may name them any names you need, , a lot of these items together with autism is now related instantly into the intestine microbiome. In truth, they’ve performed now the analysis the place they did merely a microbial transplant known as a fecal transplant they usually had been in a position to actually present that children with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They had been in a position to present once you took an individual that has a melancholy a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve performed them in mice they usually’ve performed that actually in people, and clearly, it was performed by mistake however that’s really the way it occurred.
In truth, what’s actually attention-grabbing is dependancy. They usually’ve proven the identical factor. They took…there have been 17 individuals on the analysis that had been fully hooked on alcohol. And people individuals, they gave them a fecal transplant from individuals who really had no dependancy. And these individuals’s dependancy went away. Now think about that, that our intestine microbiome are controlling our mind by way of what to do. That’s what the dependancy is, proper. And I believe that’s actually phenomenal.
And now what we’re studying is each sort of most cancers…actually what they’ve now checked out is each single stable tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide until it’s there to idiot our immune system into considering that is self and protects the tumor in opposition to the immune system attacking, proper?
Now, think about what…one other factor that’s most attention-grabbing I discovered was once you do immunotherapy, it really works about one-third of the time. And the individuals the place the immunotherapy doesn’t work, within the 70% of the those that immunotherapy didn’t work, they merely had been in a position to do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome isn’t solely there to maintain us wholesome from all of the illnesses right now we name the completely different names. Coronary heart illnesses, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In truth, we are able to now take a look at issues like LDL manufacturing which is a foul ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re in a position to take a look at how…what’s taking place in your intestine, how are we altering the inflammatory markers in our host. So, we’re in a position to measure the intestine exercise and the human host exercise, all their cytokines. So, we’re taking a look at each interleukins, we’re taking a look at the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.
And so, anyway, the purpose I’m attempting to make is that you simply talked about one thing about these micro organism, and I simply need individuals to know the microorganisms are usually not simply micro organism. They’re predominantly micro organism however additionally they encompass yeast, viruses and even the RNA viruses or fungus or mould. All of these items are literally the entire ecosystem and the largest half actually should you seen nearly 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And should you take a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, actually there are 10 instances extra phages than the micro organism alone. And meaning these viruses that infect micro organism are modifying the bacterial…the organism, the features of those micro organism that actually modifications how these micro organism behave by way of what features they’re performing.
So once more, what’s actually attention-grabbing is by taking a look at what organisms are there, won’t ever let you know what’s going on in your physique. In truth, their features are what makes the distinction. Meaning what they’re producing can…is basically the one factor that issues what these intestine microbes are producing, not who they’re. And I believe, Katie, you in all probability know that a number of the individuals like Akkermansia muciniphila. Among the corporations are promoting them as a probiotic with out realizing that Akkermansia might be good for some individuals and in reality it’s the primary motive for inflicting a number of sclerosis, and it has additionally been instantly linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one particular person and might do one thing actually unhealthy in one other particular person. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally completely different than different particular person’s physique. The identical organism or identical probiotic might be good for somebody and might be dangerous for an additional particular person. And that’s the largest studying we’ve had within the final six years.
Katie: Yeah, I like that you simply introduced up the fecal microbiota switch as properly. I’ve seen a few of the science on this and… , caveat, this isn’t one thing to try at residence however it’s fairly wonderful what they’re conducting in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you may accomplish with out having to go to that excessive if what you’re working with. And for the final two years, I’ve been saying, , early on in well being and wellness, I might discover out info, learn research and be so excited and write about it, and I’ve realized increasingly more over the past 15 years every part is so customized and so individualized. And so now when individuals ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “You already know, I can let you know what I did however it’s not gonna work the identical for you. It may be an concept with the place to begin however it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very completely different.”
Which is why I like now increasingly more entry to those at-home testing whether or not or not it’s issues like Viome, even now blood testing obtainable at residence, genetic testing simply so we are able to have extra info and entry. And I’ve mentioned so many instances on right here we’re every our personal main healthcare supplier. On the finish of the day, it’s nice to work with docs however we’re every our personal main healthcare supplier. And I really feel like having instruments in our pocket that allow us be simpler at that may actually, actually make a distinction. So, let’s discuss a bit of bit extra in regards to the personalization side of this as a result of I additionally am curious…, I do know you mentioned every part is so completely different. What’s good for one particular person may be not for an additional. Are there any issues which might be type of universally unhealthy that you simply’re discovering in Viome? Like, I might put possibly processed vegetable oils on the don’t cross record, however I’m curious what you’re seeing within the knowledge.
Naveen: Yeah. So initially, it’s actually attention-grabbing. I believe you phrased it accurately. There isn’t a such factor as common wholesome meals. And meaning there isn’t a such factor that’s good for everybody. Meaning the identical meals might be good for you or unhealthy for somebody. Nonetheless, there are some common unhealthy issues which you can know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There isn’t a one who says, “The sugar is nice for me, proper.” In order that’s really having a fried, , fried meals. So, all fried stuff, it’s simply unhealthy for everybody. Consuming a number of sugar, it’s simply unhealthy for everybody. Nonetheless, what we discover most attention-grabbing is that analyzing the human physique and analyzing based mostly on what’s going on and what’s dynamically altering in your physique…and I believe a number of the people who find themselves listening to it, I need individuals to know the distinction between a DNA which is static. So when individuals do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t let you know what is definitely happening in your physique. Meaning…if, Katie, you enable me, I’m gonna clarify the DNA as a result of I believe to me lots of people get very confused about what DNA is.
So, each a part of our physique is an identical DNA. Meaning you take a look at my hair, you take a look at my eyes, you take a look at my enamel, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Identical DNA. And the reply is there’s…when some genes are overexpressed, some genes are underneath expressed, the identical DNA can grow to be eye, identical DNA can grow to be nail, identical DNA can grow to be pores and skin, identical DNA can grow to be coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you might be writing is definitely what’s being expressed. It’s known as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each doable factor that may occur. And that’s one factor.
So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and let you know…some information to share with you in the direction of the tip. As soon as we perceive all that’s happening, we’re in a position to then let you know, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is simply too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so you must minimize it down, proper.”
We will let you know that…lots of people will let you know go take vitamin B3. However vitamin B3’s really not good for you when you have got excessive uric acid manufacturing. So don’t take vitamin B3 you probably have excessive uric acid manufacturing. Equally, everybody will let you know, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nonetheless, when your bile acid manufacturing may be very excessive, you don’t need to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people assume by some means taking NAD or NR, and NMN which is precursor to NAD is definitely improve your longevity. It’s true for some individuals it could try this, however for others it really will hurt you when you have got excessive mobile senescence, or when you have got excessive inflammatory exercise. You don’t need to be taking further NAD as a result of that’s gonna improve the mitochondrial biogenesis that’s going to extend extra free radicals, gonna improve excessive mobile senescence, proper.
So, the thought actually is that you need to study what is going on earlier than you deal with your physique like a black field. And I believe you’ve mentioned it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who must know what is going on in our physique as a result of our main care physician…I don’t find out about you, Katie. After I go to my main care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the sick, I’ll provide the capsule.” And that’s all they’re merely doing. They don’t must…they don’t care to know what’s inflicting that to occur in my physique. Like, you had Hashimoto, or should you had any sort of an autoimmune illness, the very first thing they let you know is simply take the immune suppression medication and suppress the symptom. Not fear about what’s inflicting it, and that may be a elementary downside that our healthcare system has is that our medical industrial complicated, everybody makes cash once we are sick and nobody makes cash once we are wholesome. And so, we determined to vary that. In my world of the long run, Katie, we consider that…I believe similar to you simply mentioned, the way forward for healthcare goes to be delivered at residence, not on the hospitals.
And the medicines of the long run are gonna come from a farm, not a pharmacy. And that’s going to be the largest change you’ll begin to see us taking management of our personal well being. And I believe COVID has been one of many…I might say should you look again at COVID 10 years from now, it is going to be the largest inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.
Katie: Completely. I believe so many good silver linings and instructing moments in COVID and folks spent extra time at residence and with their households cooking dinner at residence. There have been a number of nice outcomes, as onerous because it was for many individuals. I believe we are able to give attention to these positives. And I like your rationalization of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a bit of bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some large advances since then. So, speak about type of the snapshot of what Viome is testing after which how individuals are making modifications based mostly on that and what they’re seeing.
Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good however it didn’t inform us how these intestine modifications had been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t must go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re in a position to now take a look at each your intestine well being and your human host and in a position to now let you know what’s your organic age. And that tells you not solely, , how properly or how poorly your physique is getting old in comparison with your chronological age.
So, to present you an concept, I’m now gonna be 63 in September and my organic age is right down to 50. And that tells you that actually that my physique is performing on the stage after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra vitality than actually I had after I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Meaning how properly are you protected in opposition to should you had been to catch flu or chilly or any sort of pathogen, how properly your physique is ready to defend itself? And that’s your immune well being. Your mobile well being. That tells you ways properly your cells are in a position to bear the issues which might be happening within the human physique. Mitochondrial well being, that’s your vitality manufacturing facility. How properly the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We provide you with clearly your intestine well being.
And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product known as full physique intelligence. And for the primary time, we’re gonna be analyzing all the best way from high of your tube, your saliva, your stool and blood, all three on the identical time. And by taking a look at that, we’re additionally gonna be capable of present you some further insights corresponding to your coronary heart and metabolic well being. We’re gonna be supplying you with your mind and cognitive well being. We’re gonna be capable of present you your oral well being corresponding to your gum well being, your enamel well being and all of the gum, …leaky gum as an alternative of simply leaky intestine. We’ll be capable of present you ways properly your boundaries of your gums are performing in order that microbes are usually not going into your blood.
And different factor we do now which we didn’t do till a couple of yr in the past is once you do a take a look at, not solely you get your deep perception what’s taking place in your physique and never simply let you know listed below are the meals which might be good for you and right here is why. Listed here are the meals you must keep away from and why. We used to let you know listed below are the dietary supplements you must take. Now we transcend that, Katie. We’re in a position to let you know you solely want 22 milligram of berberine day-after-day. You want 17 milligram of elderberry day-after-day. You want 79 milligram amylase day-after-day. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.
There isn’t a premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the best way, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique modifications, we modify your dietary supplements on the identical time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you actually need is butyrate now,” proper. And we actually are in a position to alter your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.
Different issues that I’m actually, actually enthusiastic about…and we’ve not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a client you’ll be capable of spit in a tube and with 95% specificity and 90% sensitivity, we’ll be capable of let you know you probably have any oral most cancers or throat most cancers. After which we’ll be capable of really join you with a health care provider to have the ability to do one thing about it. So, in case you are above…over 50 years previous or have any historical past of smoking, vaping, chewing tobacco, you’ll be capable of really at residence do a take a look at and truly know that you simply’re not at a threat of creating a most cancers proper now. Otherwise you’re creating a most cancers proper now.
Katie: Yeah. That is so innovative and I believe simply to spotlight what you mentioned, that is actually fascinating information of principally machine studying and AI and this adaptive expertise. And since you’ve now examined hundreds and hundreds, in all probability a whole lot of hundreds of individuals, then the algorithm has entry to all this info so it might proceed to get increasingly more specialised and direct with the suggestions and study your individual physique over time. So, you’re getting this type of ongoing, correct image which I believe is so fascinating.
Naveen: Yeah. So, Katie, we’ve analyzed over 350,000 samples already. And that has given us this…, the a part of being the…a part of that Viome ecosystem is each single one that joins profit from the opposite 350,000 samples that we’ve analyzed they usually contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one that joins profit themselves and advantages the humanity on the identical time as a result of now the extra we study, the higher suggestions we are able to make for everybody. So, earlier than we simply solely may take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor shall be with urine. After which we’re gonna begin to take a look at different biomarkers in your physique. So, our suggestions get increasingly more exact as we study increasingly more in regards to the human physique. And our actual hope is, , in my lifetime we’ll be capable of perceive what causes the onset of a power illness and what causes them to progress and to have the ability to forestall them from taking place within the first place, to diagnose them early once they really do occur, and to give you a treatment for these illnesses. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the final word purpose of our life.
Katie: And I like that you simply introduced up the interplay of all of the completely different microbiomes inside the physique as properly and the way you’re taking a look at all of those, as a result of a few of my early analysis was in oral well being and studying as an illustration that strep mutants and the micro organism that trigger gingivitis don’t each exist on the identical time. And it’s because we’ve an oral microbiome. And if it will get out of steadiness in a single path or the opposite, you’re gonna find yourself with these issues. However the reply isn’t sterilizing your mouth and killing all micro organism similar to we wouldn’t need to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Identical factor with the intestine. And such as you mentioned, you’re taking a look at these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to speak along with her about that.
However I believe, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra type of intricate knowledge we are able to get to make enhancements over time and naturally there could be a most cancers connection right here. You already know, I’ve heard it mentioned that most cancers is a metabolic illness in some half. And it is a approach of…as a result of even inside a person, should you’re taking a look at a metabolic illness, you’re taking a look at, “Okay, we have to get blood sugar in test. We have to get blood strain in test. We have to get weight problems measures in test.” However the best way to do this’s gonna be completely different for each single particular person.
Naveen: I believe it’s a metabolic and inflammatory illness. So, I imply, it’s brought on…power irritation is a root reason for power illnesses. Nonetheless, what causes the irritation in our physique is completely different for every particular person. So though it’s the irritation that could be on the root trigger however the underlying causes for that irritation are very, very completely different. And as you talked about, our daughter is, …has this firm known as Evvy, E-V-V-Y, which seems to be on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to try this as a result of that’s actually…goes to be…, a number of ladies undergo by lots of the illnesses that we as males would by no means perceive. And that to some extent is, , largely reproductive organ and lots of the instances the later analysis reveals that vaginal microbiome is concerned in preterm start, within the well being of the child and all of the issues that you simply talked about because the child goes by the start canal. All of the issues that come out actually are contributory from the vaginal microbiome. So, my excessive suggestion…once more, I’m biased. I believe each girl needs to be doing the Evvy take a look at, proper.
Now, coming again to the stuff you talked about that, , human well being is complicated however as soon as we perceive biochemical stage what’s going on, that’s the rationale as an alternative of taking a look at organisms and as an alternative of taking a look at DNA, we centered on the gene expression or RNA. We centered on what microbes are producing. Wanting on the complete physique. And I believe, Katie, I wanna level out that the merchandise that you simply construct for oral well being are a few of the greatest merchandise as a result of, to me, what’s the largest gamechanger is individuals thought the organisms had been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t try this. If you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, , to individuals when our moms instructed us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too large to go down our esophagus, proper. It was really was once you chew your meals, you’re permitting the oral microbiome in your saliva to truly predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.
So, the primary factor is that we have to enable the oral microbiome to predigest the feed so your small gut can now soak up the vitamins which might be already predigested. So, when you find yourself…so two issues you want to take into consideration right here. And one is when you find yourself confused and you might be consuming your meals, it doesn’t get correctly digested and right here is why. If you find yourself confused, you might be in a combat or flight response. And the primary factor that occurs once you’re in combat or flight response is your digestive system shuts down. Keep in mind why it was designed. If you’re working away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And should you grew to become lunch for another person, it didn’t matter. And should you survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you might digest your meals.
If you come from work and you might be confused, what will we inform individuals? Earlier than you eat, do the gratitude. Why is that? It’s since you need to deliver your physique from sympathetic mode into parasympathetic mode. Eliminate combat or flight response. By taking the deep breath, by doing the gratitude, what you might be doing is definitely permitting your physique to have the ability to be able to digest the meals. Then once you chew your meals, you’re permitting your saliva and oral microbiome to truly predigest your meals. And these are easy strategies we realized within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, chances are you’ll not know that my mother and pa and our faith, they don’t eat after sundown. And I all the time surprise why would that be. And it seems as a result of you want to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of individuals will get three, 4 hours of digestion. So, actually telling that, …and that to me was actually the factor that we realized as a part of our tradition. Truly, seems we’re very scientific.
And I wanna come again to the oral merchandise. I believe individuals have to be actually fascinated with oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…, probiotics. And the merchandise, a few of the merchandise that you’ve got, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I believe everybody who’s listening to it to begin concentrate as a result of that’s the primary. Your mouth really is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.
Katie: I completely agree. I believe very multifaceted however begin with the mouth is so necessary. And I like a few the stuff you simply talked about about why we don’t digest meals if we’re confused and we all know, after all, that People dwell in a power state of stress typically. And one factor I’ve grow to be keen on…, there’s a motive many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you may merely do respiratory workout routines. Do some field respiratory to calm your nervous system. I like that your loved ones naturally from a spiritual perspective stopped consuming at sundown. I’ve realized in my very own life that I do nice after I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I seen after I shifted that to consuming and stopping by sundown, I really feel so significantly better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that once you’re sleeping, you might be therapeutic and your physique can get into autophagy and you’ll allocate assets to all of the pure processes the physique has in-built to maintain us wholesome.
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And I additionally wanna piggyback on what you mentioned about the identical motive we don’t wanna kill our oral microbiome is similar motive we don’t wanna kill our intestine micro organism as properly however I nonetheless see individuals type of hopping on the bandwagon of those actually harsh cleanses or after all individuals generally take antibiotics for causes whether or not they should or not. And people can each have a fairly harsh influence on the intestine. And so, I’d love to speak about it. Possibly if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine subject associated to essentially type of killing a few of these good micro organism. Clearly, Viome helps with this however type of, like, what might be performed? How can we assist repair it?
Naveen: So, very first thing is, , earlier than you go begin taking a number of issues is to know, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And then you definately begin to take a look at what you…, we let you know what are the meals you must eat. And once more, taking a number of the fermented meals particularly once you’re attempting to repopulate or rebootilate your intestine microbiome, actually the issues needs to be diversification. So as an alternative of simply taking one sort of probiotics, you ought to be taking kombucha, the kimchi, the…, all of the fermented meals you may presumably get your palms on. So, whether or not it’s a yogurt or, , at the very least oat milk yogurt should you can. I imply, I’m a giant fan that I believe dairy…actually for lots of the individuals, dairy is the large downside. Now I’m not saying it’s for everybody however a number of the individuals, dairy might be a giant downside. And the mammalian merchandise really might be a giant downside for some individuals and never for others.
So, I’m not the one that is preaching veganism right here in any respect. What I’m saying is know what is nice for you. There are lots of people who can eat purple meat for all of their life and dwell to be 100, and the rationale for that’s purple meat comprises clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the purple meat that causes the center illness. It’s the byproduct of how the purple meat is digested in some those that produce TMA. So, in case your TMA manufacturing is low, you must eat purple meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to know, don’t merely ban meals and complete class of meals.
One other factor that we realized…we revealed a paper having analyzed over 100,000 individuals at the moment on getting old. And what we discovered, Katie, that you could be discover actually fascinating is individuals who had been on these fad diets like, , keto weight-reduction plan or paleo weight-reduction plan had been the worst offender of their organic age. The individuals who had been on keto weight-reduction plan actually had been three to 5 years older than their chronological age and the identical is true for paleo weight-reduction plan. It seems that people who find themselves on balanced weight-reduction plan, meaning they had been consuming their carbs however not lots however they had been consuming their regular carbs, they had been consuming their protein, they had been consuming their fats they usually had been consuming the protein, they had been way more balanced, had been really higher off biologically than chopping out the entire nutrient group fully.
Katie: That is smart, that we want the range. And I’ve realized increasingly more as properly that I believe the simplistic model all of us realized, hopefully realized at school was about simply type of energy in, energy out. And I’ve heard it mentioned, , our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra various and necessary than that.
And what’s subsequent for Viome? I’m curious as a result of I do know you’re continually doing analysis right here, and such as you mentioned, your purpose is to deal with power illness in its entirety. So, what’s within the pipeline for you guys?
Naveen: Truly, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics increasingly more exact for each particular person since we make it for every particular person. We’re, , attempting to do further checks now and our purpose is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can not see within the blood as a result of they’re produced someplace else. So, can we measure issues, , the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict you probably have a leaky intestine by taking a look at LBP, by taking a look at CRP which really is finished within the liver? So, we’re going to have the ability to really measure further issues along with simply those that we’re measuring, and the extra info we are able to study, the higher suggestions we make. So, our hope is to proceed to launch these checks that give us higher and higher insights and meaning we are able to make increasingly more exact suggestion for every particular person.
Final purpose actually is to know…as you say, the human physique is a chemistry lab. We’ve principally biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor individuals want to know that the gene expression tells you what biochemistry is happening within the physique. And that’s a motive…and in reality, Viome is the one firm that does take a look at the gene expression as a result of there isn’t a different firm that has this expertise. And I believe individuals who have listened to your earlier podcast, we talked about, this explicit expertise got here out of Los Alamos Nationwide Lab the place that they had the laboratory for biodefense mission. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ price of assets to develop this expertise. Sadly, we had been very lucky to have the ability to get the license to have the ability to use this expertise to assist the humanity get higher. And if our mission was merely to earn money, we’d not have been in a position to license this expertise, proper.
So, the actual fact right now we’re merely centered on making each single particular person be higher. You already know, our mission on day one was what if we may perceive the human biology at a molecular stage so we are able to forestall, diagnose early and treatment these power illnesses together with most cancers and getting old? And I believe a number of the individuals who have heard you and I discuss up to now, that I misplaced my dad to most cancers and that was one of many largest motivator for me as a result of if I had began this firm half a decade earlier than I did, I may have probably saved my dad. And, , having watched him undergo that ache or struggling by most cancers I spotted that though I couldn’t save him, I may dedicate my life to saving everybody else. And that shall be my approach of letting him know that, , I’m so happy with what he…how he raised us as a baby and giving us every part we’ve so we’re in a position to save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or melancholy, nervousness or most cancers.
And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I had been to make a prediction right now, I’ll let you know inside a decade I believe we are going to eliminate most cancers from the human physique.
Katie: That’s a giant declare and I hope we’re on observe for that as properly. I’ve misplaced two prolonged relations within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m positive the power stress of the final couple of years isn’t serving to that downside. So, I’m grateful that there are assets such as you, and I’ve performed Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna make certain…I do know you’ve provided a reduction code for the Viome testing. In order that hyperlink shall be within the present notes for you guys listening at wellnessmama.fm. Yow will discover the low cost code and the hyperlink on to it there. And to verify I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a guide or quite a lot of books which have profoundly influenced your life. And if that’s the case, what they’re and why?
Naveen: Yeah, so the guide that basically influenced me…there’s a guide by Clayton Christensen, . I like the person and I noticed him earlier than he died. The guide he wrote, “How Will You Measure Your Life?” And to me it was such a profound guide which tells you that you need to be 100% sincere. You can’t be 99% sincere as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll all the time be another excuse to make an exception. And so, you need to focus your self to by no means, ever compromise in your ideas that you simply stand for. And that was simply completely a wonderful guide I learn.
You already know, the guide that additionally…I imply, clearly I wrote a guide known as “Moonshots” that’s actually about making a mindset of abundance relatively than a mindset of shortage. And the elemental perception that I’ve is that there’s nothing that people are usually not able to doing if we really get our mindset to consider we are able to. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to determine whether or not they can or they’ll’t. That when you consider one thing is inconceivable, it turns into inconceivable for you and nobody else. And so, you might be fully in management. The one factor you may’t do is what you may’t think about. Every thing else is feasible.
Katie: I like that. I do know you and I each increase our children with that mindset and yours are older and doing wonderful issues out on this planet already and mine are to start with levels of that. And lastly, what parting recommendation would you want to go away with the viewers right now? Could possibly be associated to one thing we’ve talked about or totally unrelated.
Naveen: I might say dream so large that individuals assume you’re loopy. Meaning by no means let somebody let you know which you can’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self isn’t about being self-conceited. Loving your self is about not on the lookout for another person’s approval to do the issues that imply lots to you. Observe your coronary heart, observe your intestine, take heed to your intestine and observe what it tells you. Discover a function in life. When you discover a function in life, you’ll by no means ever assume it’s work. I rise up day-after-day at 4 a.m., and that’s my recommendation to everybody. Everytime you rise up within the morning, should you’re not leaping out of the mattress, you must stop what you might be doing as a result of that’s not your calling, as a result of once you discover your calling, you’ll not be mendacity down within the mattress. You bounce out of the mattress with pleasure wanting to resolve that downside.
And, Katie, I simply need to reiterate, I met your children and I do know I keep in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to truly transfer this humanity ahead. You’re elevating these kids with the mindset that every part they need to do, they’ll. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it a number of instances. Like, once we increase our youngsters, we inform them, “Our love for you is unconditional however our approval isn’t.” And what meaning is just is that we’ll all the time love you, we’ll all the time be there for you, however I’m not gonna let you know I’m happy with you until you do issues that make us happy with you. And that’s actually the factor about telling the kids that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It is going to be measured by what number of lives they enhance. And the humility is an indication of success as a result of should you nonetheless have iota of conceitedness left in you, meaning you’re nonetheless attempting to show one thing to your self or another person. And humility tells you now not have to do this, proper. And that may be a true signal of success. And all I can say is I’m so happy with each considered one of your kids, Katie. And I can not watch for them to develop up and truly do issues that can make our youngsters’s and grandchildren’s life higher.
Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children day-after-day, “I like you unconditionally and there’s nothing you ever must do to earn my love and there’s nothing you might ever do that might take away from my love.” However you’re proper. Additionally, I need that, like, their satisfaction to return from within, like…and I inform them typically, “You should really feel actually happy with how onerous you labored and you will need to…” As a result of I need them to have that inside them and that self-love.
And for this reason I’m so grateful each single day that I get to speak to our viewers that’s listening right now of mothers, as a result of I believe mothers have such an incredible distinctive skill to essentially shift the way forward for humanity by how we mum or dad our children and by serving to kind these future leaders. And for individuals who aren’t already aware of you, I might encourage you to take heed to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these wonderful issues after which now serving to your children on their life journeys and your spouse in her personal proper is unbelievable as properly. So very grateful on your complete household and for all that each one of you might be doing on this planet and on your time right now. I understand how busy you might be and I’m so grateful you took the time to be right here.
Naveen: Oh, Katie, it’s all the time an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.
Katie: And thanks, as all the time, to all of you for listening and sharing your most useful assets, your time, your vitality, and your consideration with us right now. We’re each so grateful that you simply did. And I hope that you’ll be part of me once more on the subsequent episode of the “Wellness Mama” podcast.
If you happen to’re having fun with these interviews, would you please take two minutes to go away a ranking or evaluate on iTunes for me? Doing this helps extra individuals to search out the podcast, which suggests much more mothers and households may benefit from the data. I actually admire your time, and thanks as all the time for listening.
